In vivo recordings of brain activity using organic transistors

In vivo recordings of brain activity using organic transistors Dion Khodagholy1, Thomas Doublet1,2,3,4, Pascale Quilichini2,3, Moshe Gurfinkel1, Pierre Leleux1,2,3,4, Antoine Ghestem2,3, Esma Ismailova1, Thierry Herve ́4, Se ́bastien Sanaur1, Christophe Bernard2,3 & George G. Malliaras1 Nature Comm. 4, 1575 (2013)

http://www.nature.com/ncomms/journal/v4/n3/full/ncomms2573.html


Received 5 Apr 2012 | Accepted 5 Feb 2013 | Published 12 Mar 2013 DOI: 10.1038/ncomms2573 OPEN

In vivo recordings of brain activity using organic transistors

Dion Khodagholy1, Thomas Doublet1,2,3,4, Pascale Quilichini2,3, Moshe Gurfinkel1, Pierre Leleux1,2,3,4, Antoine Ghestem2,3, Esma Ismailova1, Thierry Herve ́4, Se ́bastien Sanaur1, Christophe Bernard2,3
& George G. Malliaras1

In vivo electrophysiological recordings of neuronal circuits are necessary for diagnostic purposes and for brain-machine interfaces. Organic electronic devices constitute a promising candidate because of their mechanical flexibility and biocompatibility. Here we demonstrate the engineering of an organic electrochemical transistor embedded in an ultrathin organic film designed to record electrophysiological signals on the surface of the brain. The device, tested in vivo on epileptiform discharges, displayed superior signal-to-noise ratio due to local amplification compared with surface electrodes. The organic transistor was able to record on the surface low-amplitude brain activities, which were poorly resolved with surface electrodes. This study introduces a new class of biocompatible, highly flexible devices for recording brain activity with superior signal-to-noise ratio that hold great promise for medical applications.

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1 Department of Bioelectronics, Ecole Nationale Supe ́rieure des Mines, CMP-EMSE, MOC, 13541 Gardanne, France. 2 Aix Marseille Universite ́, INS, 13005 Marseille, France. 3 Inserm, UMR_S 1106, 13005 Marseille, France. 4 Microvitae Technologies, Poˆle d’Activite ́ Y. Morandat, 13120 Gardanne, France. Correspondence and requests for materials should be addressed to G.G.M. (email: malliaras@emse.fr) or to C.B. (email: Christophe.Bernard@univ-amu.fr).


Nature Comm. 4, 1575 (2013)