Design and validation of electrodes for human multiscale electrophysiological recordings

Design and validation of electrodes for human multiscale electrophysiological recordings Leleux, P. (a, b,c), Bénar, C. (a), Badier, J.-M. (a), Hervé, T. (c), Malliaras, G. (b), Chauvel, P.(a) a Laboratoire Epilepsies et Cognition, INSERM U 751, Faculté de médecine secteur Timone, 27 bd Jean Moulin, 13385 Marseille cedex 05 b Centre Microélectronique de Provence, Ecole Nationale Supérieure des Mines de Saint-Etienne, 880 route de Mimet, 13541 Gardanne c Microvitae, Ecole Nationale Supérieure des Mines de Saint-Etienne, 880 route de Mimet, 13541 Gardanne

We present the fabrication, characterization and utilization of new flexible implantable neural probes. These probes are a sandwich of polyimide, platinum, conducting polymer and SU8 layers providing excellent biocompatibility, good electrical characteristics and high mechanical flexibility. The new probes are made to create a better interface with soft biological tissues and decrease damage caused by the insertion and the brain-probe micromotions.
These new materials are a good compromise between flexibility and stiffness needed for implantation and long term in vivo recording and the electrodes design is selected to provide simultaneous recordings (LFP and units) of several neurons in rat hippocampus.